Publications 2011 – 2013

2013
Pinto, L.M., Dheda, K., Theron, G., Allwood, B., Calligaro, G., van Zyl-Smit, R., Peter, J., Schwartzman, K., Menzies, D., Bateman, E., Pai, M., Dawson, R. Development of a Simple Reliable Radiographic Scoring System to Aid the Diagnosis of Pulmonary Tuberculosis. PLoS ONE. 2013; 8(1). doi:10.1371/journal.pone.0054235.
Kalsdorf, B., Skolimowska, K.H., Scriba, T.J., Dawson, R., Dheda, K., Wood, K., Hofmeister, J., Hanekom, W.A., Lange, C., Wilkinson, R.J. Relationship between chemokine receptor expression, chemokine levels and HIV-1 replication in the lungs of persons exposed to Mycobacterium tuberculosis. European Journal of Immunology. 2013; 43(2);540-549. doi:10.1002/eji.201242804.
Nolan, A., Fajardo, E., Huie, M.L., Condos, R., Pooran, A., Dawson, R., Dheda, K., Bateman, E., Rom, W.N., Weiden, M.D. Increased Production of IL-4 and IL-12p40 from Bronchoalveolar Lavage Cells Are Biomarkers of Mycobacterium tuberculosis in the Sputum. PLoS ONE. 2013; 8(30). doi:10.1371/journal.pone.0059461.
Kolwijck, E., Mitchell, M., Venter, A., Friedrich, S.O., Dawson, R., Diacon, A.H. Short-term storage does not affect the quantitative yield of mycobacterium tuberculosis in sputum in early-bactericidal-activity studies. Journal of Clinical Microbiology. 2013; 51(4):1094-1098. doi:10.1128/JCM.02751-12.
Diacon, A.H., Dawson, R., Von Groote-Bidlingmaier, F., Symons, G., Venter, A., Donald, P.R., Conradie, A., Erondu, N., Ginsberg, A.M., Egizi, E., Winter, H., Becker, P., Mendel, C.M. Randomized dose-ranging study of the 14-day early bactericidal activity of bedaquiline (TMC207) in patients with sputum microscopy smear-positive pulmonary tuberculosis. Antimicrobial Agents and Chemotherapy. 2013; 57(5):2199-2203. doi:10.1128/AAC.02243-12.
Kayigire, X.A., Friedrich, S.O., Venter, A., Dawson, R., Gillespie, S.H., Boeree, M.J., Heinrich, N., Hoelscher, M., Diacon, A.H. Direct comparison of Xpert MTB/RIF assay with liquid and solid mycobacterial culture for quantification of early bactericidal activity. Journal of Clinical Microbiology. 2013; 51(6):1894-1898. doi:10.1128/JCM.03290-12.
Nolan, A., Condos, R., Huie, M.L., Dawson, R., Dheda, K., Bateman, E., Rom, W.N., Weiden, M.D. Elevated IP-10 and IL-6 from bronchoalveolar lavage cells are biomarkers of non-cavitary tuberculosis. International Journal of Tuberculosis and Lung Disease. 2013; 17(7):922-927. doi:10.5588/ijtld.12.0610.
Dawson, R., Diacon, A. PA-824, moxifloxacin and pyrazinamide combination therapy for tuberculosis. Expert Opinion on Investigational Drugs. 2013; 22(7):927-932. doi:10.1517/13543784.2013.801958.
Friedrich, S.O., Rachow, A., Saathoff, E., Singh, K., Mangu, C.D., Dawson, R., Phillips, P.P.J., Venter, A., Bateson, A., Boehme, C.C., Heinrich, N., Hunt, R.D., Boeree, M.J., Zumla, A., McHugh, T.D., Gillespie, S.H., Diacon, A.H., Hoelscher, M. Assessment of the sensitivity and specificity of Xpert MTB/RIF assay as an early sputum biomarker of response to tuberculosis treatment. The Lancet Respiratory Medicine. 2013; 1(6):462470. doi:10.1016/S2213-2600(13)70119-X.
Bryant, J.M., Harris, S.R., Parkhill, J., Dawson, R., Diacon, A.H., van Helden, P., Pym, A., Mahayiddin, A.A., Chuchottaworn, C., Sanne, I.M., Louw, C., Boeree, M.J., Hoelscher, M., McHugh, T.D., Bateson, A.L.C., Hunt, R.D., Mwaigwisya, S., Wright, L., Gillespie, S.H., Bentley, S.D. Whole-genome sequencing to establish relapse or re-infection with Mycobacterium tuberculosis: A retrospective observational study. The Lancet Respiratory Medicine. 2013; 1(10):786-792. doi:10.1016/S2213-2600(13)70231-5.
2012
Diacon, A.H., Dawson, R., Du Bois, J., Narunsky, K., Venter, A., Donald, P.R., Van Niekerk, C., Erondu, N., Ginsberg, A.M., Becker, P., Spigelman, M.K. Phase II dose-ranging trial of the early bactericidal activity of PA-824. Antimicrobial Agents and Chemotherapy. 2012; 56(6):3027-3031. doi:10.1128/AAC.06125-11.
Theron, G., Pooran, A., Peter, J., Van Zyl-Smit, R., Mishra, H.K., Meldau, R., Calligaro, G., Allwood, B., Sharma, S.K., Dawson, R., Dheda, K. Do adjunct tuberculosis tests, when combined with Xpert MTB/RIF, improve accuracy and the cost of diagnosis in a resource-poor setting? European Respiratory Journal. 2012; 40(1):161-168. doi:10.1183/09031936.00145511.
Diacon, A.H., Maritz, J.S., Venter, A., Van Helden, P.D., Dawson, R., Donald, P.R. Time to liquid culture positivity can substitute for colony counting on agar plates in early bactericidal activity studies of antituberculosis agents. Clinical Microbiology and Infection. 2012; 18(7):711-717. doi:10.1111/j.1469-0691.2011.03626.x.
Diacon, A.H., Dawson, R., Von Groote-Bidlingmaier, F., Symons, G., Venter, A., Donald, P.R., Van Niekerk, C., Everitt, D., Winter, H., Becker, P., Mendel, C.M., Spigelman, M.K.14-day bactericidal activity of PA-824, bedaquiline, pyrazinamide, and moxifl oxacin combinations: A randomised trial. The Lancet. 2012; 380(9846):986-993. doi:10.1016/S0140-6736(12)61080-0.
Dheda, K., Theron, G., Peter, J.G., Symons, G., Dawson, R., Willcox, P. TB drug resistance in high-incidence countries. European Respiratory Monograph. 2012; 58:95-110. doi:10.1183/1025448x.

2011
Van Ingen, J., Aarnoutse, R.E., Donald, P.R., Diacon, A.H., Dawson, R., Plemper Van Balen, G., Gillespie, S.H., Boeree, M.J. Why do we use 600 mg of rifampicin in tuberculosis treatment? Clinical Infectious Diseases. 2011; 52(9):e194-e199. doi:10.1093/cid/cir184.
Segal, L.N., Methé, B.A., Nolan, A., Hoshino, Y., Rom, W.N., Dawson, R., Bateman, E., Weiden, M.D.HIV-1 and bacterial pneumonia in the era of antiretroviral therapy. Proceedings of the American Thoracic Society. 2011; 8(3):282-287. doi:10.1513/pats.201006-044WR.
Theron, G., Peter, J., Van Zyl-Smit, R., Mishra, H., Streicher, E., Murray, S., Dawson, R., Whitelaw, A., Hoelscher, M., Sharma, S., Pai, M., Warren, R., Dheda, K. Evaluation of the Xpert MTB/RIF assay for the diagnosis of pulmonary tuberculosis in a high HIV prevalence setting. American Journal of Respiratory and Critical Care Medicine. 2011; 184(1):132-140. doi:10.1164/rccm.201101-0056OC.
Diacon, A.H., Dawson, R., Hanekom, M., Narunsky, K., Venter, A., Hittel, N., Geiter, L.J., Wells, C.D., Paccaly, A.J., Donald, P.R. Early bactericidal activity of delamanid (OPC-67683) in smear-positive pulmonary tuberculosis patients. International Journal of Tuberculosis and Lung Disease. 2011; 15(7):949-954. doi:10.1164/rccm.201101-0056OC.
Brunet, L., Pai, M., Davids, V., Ling, D., Paradis, G., Lenders, L., Meldau, R., Van Zyl Smit, R., Calligaro, G., Allwood, B., Dawson, R., Dheda, K. High prevalence of smoking among patients with suspected tuberculosis in South Africa European Respiratory Journal. 2011; 38(1):139-146. doi:10.1183/09031936.00137710.
Friedrich, S.O., Venter, A., Kayigire, X.A., Dawson, R., Donald, P.R., Diacon, A.H. Suitability of Xpert MTB/RIF and genotype MTBDRplus for patient selection for a tuberculosis clinical trial. Journal of Clinical Microbiology. 2011; 49(8):2827-2831. doi:10.1128/JCM.00138-11.
Ling, D.I., Pai, M., Davids, V., Brunet, L., Lenders, L., Meldau, R., Calligaro, G., Allwood, B., Van Zyl-Smit, R., Peter, J., Bateman, E., Dawson, R., Dheda, K. Are interferon-γ release assays useful for diagnosing active tuberculosis in a high-burden setting? European Respiratory Journal. 2011; 38(3):649-656. doi:10.1183/09031936.00181610.
Matthews, K., Wilkinson, K.A., Kalsdorf, B., Roberts, T., Diacon, A., Walzl, G., Wolske, J., Ntsekhe, M., Syed, F., Russell, J., Mayosi, B.M., Dawson, R., Dheda, K., Wilkinson, R.J., Hanekom, W.A., Scriba, T.J. Predominance of interleukin-22 over interleukin-17 at the site of disease in human tuberculosis. Tuberculosis. 2011; 587-593. doi:10.1016/j.tube.2011.06.009.