Publications 2014 – 2015

Philipsen, R.H.H.M., Sánchez, C.I., Maduskar, P., Melendez, J., Peters-Bax, L., Peter, J.G., Dawson, R., Theron, G., Dheda, K., Van Ginneken, B. Automated chest-radiography as a triage for Xpert testing in resource-constrained settings: A prospective study of diagnostic accuracy and costsScientific Reports. 2015; doi:10.1016/S0140-6736(14)62002-X
Calligaro, G.L., Theron, G., Khalfey, H., Peter, J., Meldau, R., Matinyenya, B., Davids, M., Smith, L., Pooran, A., Lesosky, M., Esmail, A., Miller, M.G., Piercy, J., Michell, L., Dawson, R., Raine, R.I., Joubert, I., Dheda, K. Burden of tuberculosis in intensive care units in Cape Town, South Africa, and assessment of the accuracy and effect on patient outcomes of the Xpert MTB/RIF test on tracheal aspirate samples for diagnosis of pulmonary tuberculosis: A prospective burden of disease study with a nested randomised controlled trialThe Lancet Respiratory Medicine. 3(8):621-630. doi:10.1016/S2213-2600(15)00198-8
Bowness, R., Boeree, M.J., Aarnoutse, R., Dawson, R., Diacon, A., Mangu, C., Heinrich, N., Ntinginya, N.E., Kohlenberg, A., Mtafya, B., Phillips, P.P.J., Rachow, A., Plemper van balen, G., Gillespie, S.H. The relationship between mycobacterium tuberculosis mgit time to positivity and cfu in sputum samples demonstrates changing bacterial phenotypes potentially reflecting the impact of chemotherapy on critical sub-populations. Journal of Antimicrobial Chemotherapy. 2015; 70(2):448-455. doi:10.1093/jac/dku415.
Dawson, R., Narunsky, K., Carman, D., Gupte, N., Whitelaw, A., Efron, A., Barnes, G.L., Hoffman, J., Chaisson, R.E., McIlleron, H., Dorman, S.E. Two-stage activity-safety study of daily rifapentine during intensive phase treatment of pulmonary tuberculosis. International Journal of Tuberculosis and Lung Disease. 2015; 19(7):780-786. doi:10.5588/ijtld.14.0868.
Boeree, M.J., Diacon, A.H., Dawson, R., Narunsky, K., Du Bois, J., Venter, A., Phillips, P.P.J., Gillespie, S.H., McHugh, T.D., Hoelscher, M., Heinrich, N., Rehal, S., Van Soolingen, D., Van Ingen, J., Magis-Escurra, C., Burger, D., Van Balen, G.P., Aarnoutse, R.E. A dose-ranging trial to optimize the dose of rifampin in the treatment of tuberculosis. American Journal of Respiratory and Critical Care Medicine. 2015; 191(9):1058-1065. doi:10.1164/rccm.201407-1264OC.
Adams, S., Ehrlich, R., Baatjies, R., Van Zyl-Smit, R.N., Said-Hartley, Q., Dawson, R., Dheda, K. Incidence of occupational latent tuberculosis infection in South African healthcare workers. European Respiratory Journal. 2015; 45(5):1364-1373. doi:10.1183/09031936.00138414.
Diacon, A.H., Dawson, R., Von Groote-Bidlingmaier, F., Symons, G., Venter, A., Donald, P.R., Van Niekerk, C., Everitt, D., Hutchings, J., Burger, D.A., Schall, R., Mendel, C.M. Bactericidal activity of pyrazinamide and clofazimine alone and in combinations with pretomanid and bedaquiline. American Journal of Respiratory and Critical Care Medicine. 2015; 191(8):943-953. doi:10.1164/rccm.201410-1801OC.
Dawson, R., Diacon, A.H., Everitt, D., Van Niekerk, C., Donald, P.R., Burger, D.A., Schall, R., Spigelman, M., Conradie, A., Eisenach, K., Venter, A., Ive, P., Page-Shipp, L., Variava, E., Reither, K., Ntinginya, N.E., Pym, A., Von Groote-Bidlingmaier, F., Mendel, C.M. Efficiency and safety of the combination of moxifloxacin, pretomanid (PA-824), and pyrazinamide during the first 8 weeks of antituberculosis treatment: A phase 2b, open-label, partly randomised trial in patients with drug-susceptible or drug-resistant pulmonary tuberculosis. The Lancet. 2015; 385(9979):1738-1747. doi:10.1016/S0140-6736(14)62002-X.


Maduskar, P., Hogeweg, L., De Jong, P.A., Peters-Bax, L., Dawson, R., Ayles, H., Sánchez, C.I., Van Ginneken, B. Cavity contour segmentation in chest radiographs using supervised learning and dynamic programming. Medical Physics. 2014; 41(7). doi:10.1118/1.4881096.
Wallis, R.S., Dawson, R., Friedrich, S.O., Venter, A., Paige, D., Zhu, T., Silvia, A., Gobey, J., Ellery, C., Zhang, Y., Eisenach, K., Miller, P., Diacon, A.H. Mycobactericidal activity of sutezolid (PNU-100480) in sputum (EBA) and blood (WBA) of patients with pulmonary tuberculosis. PLoS ONE. 2014; 9(4). doi:10.1371/journal.pone.0094462.
Weiden, M.D., Hoshino, S., Levy, D.N., Li, Y., Kumar, R., Burke, S.A., Dawson, R., Hioe, C.E., Borkowsky, W., Rom, W.N., Hoshino, Y.Adenosine deaminase acting on RNA-1 (ADAR1) Inhibits HIV-1 replication in human alveolar macrophages. PLoS ONE. 2014; 9(10). doi:10.1371/journal.pone.0108476.