CAMRA

Centre for the Study of Antimicrobial Resistance (CAMRA) - An SA MRC Extramural Unit

Professor Dheda and the CLII were recently awarded funding by the South African Medical Research Council to become an Extramural Unit (EMU) to tackle the growing problem of antimicrobial resistance (AMR) in South Africa. EMUs are prestigious and highly rated external research divisions commissioned by the MRC to conduct research on its behalf. The EMU, the Centre for the Study of Antimicrobial Resistance (CAMRA), will be embedded within the CLII and will bring together a multi-disciplinary group of national and international experts to address specific questions related to mycobacterial (TB) and bacterial multi-drug-resistant (MDR) pathogens including Klebsiella pneumoniae, MDR Pseudomonas, MDR Acinetobacter, and carbapenem-resistant enterobacteriaceae (CRE). The central theme of CAMRA is Pharmacokinetic (PK) Mismatch (its drivers, its consequences, and how it can be corrected). PK mismatch refers to sub-lethal and suboptimal drug concentrations at the disease site. We will study the relationship between PK mismatch and the development of drug resistance, and corrective strategies such as better diagnostic readouts to detect mismatch, and newer approaches to drug delivery including inhaled drug formulations. There are also important capacity development aspects. The proposed activities of CAMRA are summarized into three aims with a focus on drug resistant tuberculosis (MDR, XDR) and other prevalent MDR bacterial pathogens.


Key South African members

  1. CAMRA Director - Prof Keertan Dheda (Professor of Respiratory Medicine, University of Cape Town)
  2. Prof. Gary Maartens (Professor of Clinical Pharmacology, University of Cape Town)
  3. Prof. Koleka Mlisana (Head of Department of Medical Microbiology, University of KwaZulu Natal)
  4. Prof Bernard Fourie (Research Professor (Extraordinary) of Medical Microbiology, University of Pretoria)
  5. Prof. Robin Warren (Unit Director SAMRC Council Centre for TB Research, Stellenbosch University)
  6. A/ Prof. Olga Perovic (Lead Antimicrobial Resistance Laboratory and Culture Collection, National Institute of Communicable Diseases)
  7. Dr. Nazir Ismail (Head of the Centre for Tuberculosis, National Institute of Communicable Diseases)

Key International members

  1. Prof. Taane Clark (Professor of Genomics and Global Health, London School of Hygiene and Tropical Medicine, London, UK)
  2. A/ Prof Francesca Buttini (University of Parma, Parma, Italy)
  3. Prof. Tawanda Gumbo (Director of CIDRET, Baylor Scott & White Research Institute, Dallas, Texas, USA)

Collaborators

  1. Prof. Peter Smith (Division of Clinical Pharmacology, University of Cape Town)
  2. Dr Malcom Miller and Prof. Ivan Joubert (ICU at University of Cape Town/Groote Schuur Hospital)
  3. Prof Patrick Olubuyo (Head of Department of Pulmonary Medicine, Walter Sisulu University)
  4. Dr. Carol Maluleka (MBCHB, MMed); Pathologist (Microbiology); Sefako Makgatho University: NHLS/ Lecturer (UL)

Read More:

Article 1: Centre for the Study of Antimicrobial Resistance
Article 2: Problem of antibiotic resistance under unprecedented scrutiny by new unit

Do NOT follow this link or you will be banned from the site!